Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.60 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.56 |
| ▸ | XDH | P47989 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 3/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1800349 | 0.82 | ASIC3 (0.60) | ASIC3ADORA2A | |
| SCHEMBL18039077 | 0.82 | ASIC3 (0.47) | CTSSASIC3XDHKDM1AIDO1 | |
| SCHEMBL1358158 | 0.80 | XDH (0.57) | CTSSXDHKDM1AIDO1KMO | |
| SCHEMBL2615262 | 0.79 | CTSS (0.60) | CTSSXDHKDM1AIDO1KMO | |
| SCHEMBL4787 | 0.79 | CTSS (0.60) | CTSSXDHKDM1AIDO1KMO | |
| SCHEMBL3999574 | 0.79 | CTSS (0.60) | CTSSXDHKDM1AIDO1KMO | |
| SCHEMBL2302878 | 0.79 | CTSS (0.56) | CTSSXDHKDM1AIDO1KMO | |
| SCHEMBL2788482 | 0.79 | CCNT1 (0.63) | CTSSXDHKDM1AIDO1KMO | |
| SCHEMBL7711733 | 0.79 | ADORA2A (0.53) | CTSSXDHKDM1AIDO1ADORA2A | |
| SCHEMBL10853666 | 0.78 | CNR2 (0.53) | CTSSXDHKDM1AIDO1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |