Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20223362 | 0.87 | ATM (0.38) | ALDH1A1SMN1; SMN2ATMHPGDKDM4E | |
| SCHEMBL17610932 | 0.86 | ATM (0.37) | ALDH1A1SMN1; SMN2ATMHPGDKDM4E | |
| SCHEMBL17610976 | 0.85 | KDM4E (0.39) | ALDH1A1SMN1; SMN2ATMHPGDKDM4E | |
| SCHEMBL17610982 | 0.83 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2ATMHPGDKDM4E | |
| SCHEMBL17619374 | 0.81 | LMNA (0.41) | ALDH1A1SMN1; SMN2HPGDKDM4EHSD17B10 | |
| SCHEMBL17610927 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2ATMHPGDKDM4E | |
| SCHEMBL17610926 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2ATMHPGDKDM4E | |
| SCHEMBL17619377 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2ATMHPGDKDM4E | |
| SCHEMBL17610960 | 0.79 | GUCY1B2 (0.38) | SMN1; SMN2ATMPKM | |
| SCHEMBL17610997 | 0.76 | PKM (0.38) | ALDH1A1SMN1; SMN2ATMHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844064-B2 | sGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-20180155345-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-06-07 | — | — | US | disclosed |
| US-20180155345-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-06-07 | — | — | US | disclosed |
| EP-3194386-A2 | SGC STIMULATORS | Ironwood Pharmaceuticals, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044446-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2016044446-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844064-B2 | sGC stimulators | GUCY1B1, GUCY1A1, PRKG1 | ALDH1A1 1902/4885SMN1; SMN2 3173/4885ATM 712/4885 |
| US-20180155345-A1 | sGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG1 | ALDH1A1 1902/4885SMN1; SMN2 3173/4885ATM 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.