Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13285783 | 0.81 | RIPK1 (0.38) | RIPK1ACHEBACE1 | |
| SCHEMBL2276427 | 0.77 | RIPK1 (0.42) | RIPK1ATR | |
| SCHEMBL17613247 | 0.76 | LMNA (0.30) | — | |
| SCHEMBL16446528 | 0.75 | MAPT (0.51) | RIPK1 | |
| Hydrochloric Acid SCHEMBL16569842 | 0.74 | ADRB1 (0.37) | RIPK1 | |
| SCHEMBL22686232 | 0.71 | RIPK1 (0.35) | RIPK1 | |
| SCHEMBL15784084 | 0.70 | MAPT (0.56) | RIPK1ACHEBACE1ATR | |
| SCHEMBL14470151 | 0.67 | RIPK1 (0.39) | RIPK1 | |
| SCHEMBL18971164 | 0.67 | PSEN1 (0.38) | RIPK1 | |
| SCHEMBL21050393 | 0.67 | PSEN1 (0.38) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788333-B1 | 1,2,4-TRIAZOLES AS ALLOSTERIC MODULATORS OF MGLU5 RECEPTOR ACTIVITY FOR THE TREATMENT OF SCHIZOPHRENIA OF DEMENTIA | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |