Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613344 | 0.90 | FABP4 (0.41) | MCL1ALDH1A1FABP4FABP5HSD17B10 | |
| SCHEMBL17599324 | 0.80 | MEN1 (0.47) | KMT2AMCL1KDM4EALDH1A1MEN1 | |
| SCHEMBL17613380 | 0.76 | PTGER1 (0.37) | KMT2AMEN1FABP4FABP5 | |
| SCHEMBL17599358 | 0.69 | ALDH1A1 (0.58) | KMT2AMCL1KDM4EALDH1A1MEN1 | |
| SCHEMBL22319386 | 0.67 | NR4A2 (0.55) | SLC6A4SLC6A3KMT2AMCL1KDM4E | |
| SCHEMBL17599470 | 0.67 | MEN1 (0.46) | KMT2AKDM4EALDH1A1MEN1LMNA | |
| SCHEMBL16548130 | 0.66 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2KMT2AMCL1 | |
| SCHEMBL17613338 | 0.65 | NR1H4 (0.41) | — | |
| SCHEMBL16548241 | 0.65 | SLC6A3 (0.45) | SLC6A4SLC6A3SLC6A2KMT2AMCL1 | |
| SCHEMBL29188757 | 0.62 | SLC6A4 (0.49) | SLC6A4SLC6A3KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |