SCHEMBL17614232

SCHEMBL17614232

CC(C)(C)NC(=S)SC(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
EPHX1 P07099 1/20 0.36
NOS1 P29475 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21641661 0.97 MEN1 (0.46) MEN1KMT2AEPHX1NOS1
SCHEMBL27562845 0.97 MEN1 (0.46) MEN1KMT2AEPHX1NOS1
SCHEMBL19485090 0.74
SCHEMBL8320893 0.74
SCHEMBL8320888 0.72
SCHEMBL19484938 0.69 MEN1 (0.43) MEN1KMT2AEPHX1
SCHEMBL11571739 0.67
SCHEMBL9910982 0.67 EPHX1 (0.36) MEN1KMT2AEPHX1NOS1
SCHEMBL1276388 0.65 MEN1 (1.00) MEN1KMT2AEPHX1
SCHEMBL10668659 0.65 NOS1 (0.40) MEN1KMT2ANOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11116849-B2 Hydrogel-linked prodrugs releasing tagged drugs ASCENDIS PHARMA A/S (DK) 2021-09-14 US disclosed
US-10653795-B2 2020-05-19 US disclosed
US-20160082123-A1 Hydrogel-Linked Prodrugs Releasing Tagged Drugs ASCENDIS PHARMA A/S (DK) 2016-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10653795-B2 PTMS, MSN, CD44 MEN1 3272/4885KMT2A 3217/4885EPHX1 126/4885
US-20160082123-A1 Hydrogel-Linked Prodrugs Releasing Tagged Drugs PTMS, PGLS, PAM MEN1 3497/4885KMT2A 2556/4885EPHX1 164/4885
US-11116849-B2 Hydrogel-linked prodrugs releasing tagged drugs PTMS, PGLS, PAM MEN1 3497/4885KMT2A 2556/4885EPHX1 164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.