Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | SERPINA3 | P01011 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17617642 | 0.89 | FGFR1 (0.41) | TLR9TLR7HSP90AA1HSP90AB1NR3C1 | |
| SCHEMBL19770643 | 0.88 | TP53 (0.36) | TLR9TLR7HSP90AA1HSP90AB1NR3C1 | |
| SCHEMBL18665248 | 0.88 | POLB (0.38) | TLR9TLR7HSP90AA1HSP90AB1SERPINA3 | |
| SCHEMBL7867774 | 0.78 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1NR3C1MAPTCTSL | |
| SCHEMBL24790410 | 0.77 | NR3C1 (0.36) | HSP90AA1HSP90AB1SERPINA3NR3C1 | |
| SCHEMBL2606971 | 0.75 | HSP90AB1 (0.47) | HSP90AA1HSP90AB1 | |
| SCHEMBL14175362 | 0.73 | CDK1 (0.41) | CDK5CDK5R1 | |
| SCHEMBL17617648 | 0.73 | TLR9 (0.31) | TLR9TLR7 | |
| SCHEMBL14175366 | 0.72 | CCNB2 (0.35) | CDK5CDK5R1 | |
| SCHEMBL14175374 | 0.72 | CCNB2 (0.40) | CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180015095-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-01-18 | — | — | US | disclosed |
| US-9801884-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-31 | — | — | US | disclosed |
| WO-2017048956-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-23 | — | — | WO | disclosed |
| US-20170037068-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-02-09 | — | — | US | disclosed |
| US-9493493-B2 | Nucleotide analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160083407-A1 | NUCLEOTIDE ANALOGS | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2016-03-24 | — | — | US | disclosed |
| WO-2016044281-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180015095-A1 | NUCLEOTIDE ANALOGS | NUDT1, DUT, DPYD | TLR9 744/4885TLR7 895/4885HSP90AA1 2377/4885 |
| US-20160083407-A1 | NUCLEOTIDE ANALOGS | NUDT1, DUT, DPYD | TLR9 744/4885TLR7 895/4885HSP90AA1 2377/4885 |
| US-20170037068-A1 | NUCLEOTIDE ANALOGS | NUDT1, DUT, DPYD | TLR9 744/4885TLR7 895/4885HSP90AA1 2377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.