Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 8/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16238365 | 0.96 | HTR2C (0.41) | HTR2CTRPV1HTR2AMCHR1MAP4K4 | |
| SCHEMBL16754613 | 0.96 | HTR2C (0.41) | HTR2CTRPV1HTR2AMCHR1MAP4K4 | |
| Hydrochloric Acid SCHEMBL16238891 | 0.95 | HTR2C (0.40) | HTR2CTRPV1HTR2AMCHR1MAP4K4 | |
| Hydrochloric Acid SCHEMBL16238890 | 0.95 | HTR2C (0.40) | HTR2CTRPV1HTR2AMCHR1MAP4K4 | |
| SCHEMBL19706148 | 0.86 | NPC1 (0.39) | HTR2CTRPV1HTR2AMCHR1HRH4 | |
| SCHEMBL20632429 | 0.85 | MAP4K4 (0.38) | HTR2CMCHR1MAP4K4HRH4HRH3 | |
| SCHEMBL16776029 | 0.83 | RPS6KA3 (0.39) | HTR2CTRPV1HTR2AMCHR1HRH4 | |
| SCHEMBL17618523 | 0.83 | MCHR1 (0.38) | MCHR1MAP4K4HRH4HRH3 | |
| SCHEMBL19670269 | 0.83 | MCHR1 (0.38) | HTR2CTRPV1HTR2AMCHR1MAP4K4 | |
| SCHEMBL17618524 | 0.82 | LCK (0.39) | MCHR1MAP4K4HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044338-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2018-02-15 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083386-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HTR2C 4649/4885TRPV1 4249/4885HTR2A 4359/4885 |
| US-20180044338-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HTR2C 4649/4885TRPV1 4249/4885HTR2A 4359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.