Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618339 | 0.86 | HTR2C (0.41) | HTR2CHTR2ATRPV1MCHR1HRH4 | |
| SCHEMBL16238365 | 0.86 | HTR2C (0.41) | HTR2CHTR2AMAPTTRPV1MCHR1 | |
| SCHEMBL16754613 | 0.86 | HTR2C (0.41) | HTR2CHTR2AMAPTTRPV1MCHR1 | |
| SCHEMBL16776029 | 0.85 | RPS6KA3 (0.39) | HTR2CHTR2ATRPV1CACNA1GCACNA1H | |
| Hydrochloric Acid SCHEMBL16238890 | 0.85 | HTR2C (0.40) | HTR2CHTR2AMAPTBLMPMP22 | |
| Hydrochloric Acid SCHEMBL16238891 | 0.85 | HTR2C (0.40) | HTR2CHTR2AMAPTBLMPMP22 | |
| SCHEMBL19865071 | 0.81 | HTR2C (0.47) | NPC1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19670269 | 0.80 | MCHR1 (0.38) | HTR2CHTR2ATRPV1MCHR1ACACB | |
| SCHEMBL20632222 | 0.79 | NPC1 (0.36) | NPC1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20632429 | 0.77 | MAP4K4 (0.38) | HTR2CMAPTMCHR1ACACBHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355697-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | NPC1 3380/4885TP53 349/4885CYP1A2 3492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.