Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670272 | 0.87 | MCHR1 (0.37) | MCHR1HRH4HRH3P2RX7MAP4K4 | |
| SCHEMBL19670278 | 0.87 | MCHR1 (0.37) | MCHR1HRH4HRH3P2RX7MAP4K4 | |
| SCHEMBL19670447 | 0.86 | PDE10A (0.39) | MCHR1HRH4HRH3PDE10AP2RX7 | |
| SCHEMBL19670280 | 0.85 | MCHR1 (0.37) | MCHR1HRH4HRH3P2RX7MAP4K4 | |
| SCHEMBL17618339 | 0.83 | HTR2C (0.41) | MCHR1HRH4HRH3HTR2CHTR2A | |
| SCHEMBL16754613 | 0.82 | HTR2C (0.41) | MCHR1HRH4HRH3HTR2CHTR2A | |
| SCHEMBL16238365 | 0.82 | HTR2C (0.41) | MCHR1HRH4HRH3HTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL16238891 | 0.81 | HTR2C (0.40) | MCHR1HRH4HRH3HTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL16238890 | 0.81 | HTR2C (0.40) | MCHR1HRH4HRH3HTR2CHTR2A | |
| SCHEMBL19670276 | 0.81 | JAK2 (0.40) | MCHR1HRH4HRH3GAAPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |