Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.48 |
| ▸ | PDE9A | O76083 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 3/20 | 0.33 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1740371 | 0.85 | KDM5A (0.46) | KDM5APDE9AP2RX7CYP1A2FAAH | |
| SCHEMBL2993386 | 0.77 | GPR119 (0.44) | KDM5ANAMPT | |
| SCHEMBL13075972 | 0.74 | KDM5A (0.39) | KDM5APDE9ACHRNB4CHRNA3CHRNA7 | |
| SCHEMBL17620811 | 0.72 | KDM5A (0.37) | KDM5AP2RX7CYP1A2SLC6A7 | |
| SCHEMBL1963995 | 0.72 | PRMT5 (0.39) | KDM5A | |
| SCHEMBL15529416 | 0.71 | NAMPT (0.60) | KDM5ANAMPT | |
| SCHEMBL17675448 | 0.71 | CYP11B2 (0.42) | KDM5APDE9A | |
| SCHEMBL29765569 | 0.70 | — | — | |
| SCHEMBL16060787 | 0.70 | — | — | |
| SCHEMBL3393553 | 0.70 | GOT1 (0.37) | KDM5APDE9AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296723-B2 | NAMPT inhibitors | ABBVIE INC. (US) | 2016-03-29 | — | — | US | disclosed |