Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | ICMT | O60725 | 14/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | FNTA | P49354 | 1/20 | 0.54 |
| ▸ | FNTB | P49356 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1762104 | 1.00 | MAPT (0.97) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL1762100 | 1.00 | MAPT (0.97) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL1648111 | 0.99 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL1648108 | 0.99 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL2818645 | 0.99 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL664393 | 0.99 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL4024890 | 0.99 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL8025173 | 0.99 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL5274733 | 0.99 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL2818639 | 0.99 | MAPT (1.00) | MAPTALDH1A1ICMTMEN1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765376-B1 | Topical compositions and use thereof for the treatment of epithelial-related conditions | SIGNUM BIOSCIENCES INC (US) | 2013-04-10 | — | — | EP | claimed |
| EP-1765376-A4 | TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS | SIGNUM BIOSCIENCES INC (US) | 2009-04-22 | — | — | EP | claimed |
| EP-1765376-A1 | TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS | SIGNUM BIOSCIENCES, INC. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2005123103-A1 | TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS | SIGNUM BIOSCIENCES, INC. (US) | 2005-12-29 | — | — | WO | claimed |
| US-20050277694-A1 | Topical compositions and methods for epithelial-related conditions | SIGNUM BIOSCIENCES, INC. (US) | 2005-12-15 | — | — | US | claimed |
| EP-1765376-B1 | Topical compositions and use thereof for the treatment of epithelial-related conditions | SIGNUM BIOSCIENCES INC (US) | 2013-04-10 | — | — | EP | disclosed |
| US-8338648-B2 | Topical compositions and methods for epithelial-related conditions | SIGNUM BIOSCIENCES, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8334413-B2 | Topical compositions and methods for epithelial-related conditions | SIGNUM BIOSCIENCES, INC. (US) | 2012-12-18 | — | — | US | disclosed |
| US-20110117187-A1 | TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS | SIGNUM BIOSCIENCES, INC. (US) | 2011-05-19 | — | — | US | disclosed |
| EP-1765376-A4 | TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS | SIGNUM BIOSCIENCES INC (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1765376-A1 | TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS | SIGNUM BIOSCIENCES, INC. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123103-A1 | TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS | SIGNUM BIOSCIENCES, INC. (US) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277694-A1 | Topical compositions and methods for epithelial-related conditions | KRT18, CUTA, SERPINB1 | MAPT 2316/4885ALDH1A1 2524/4885ICMT 4670/4885 |
| US-20110117187-A1 | TOPICAL COMPOSITIONS AND METHODS FOR EPITHELIAL-RELATED CONDITIONS | KRT18, CUTA, SERPINB1 | MAPT 2316/4885ALDH1A1 2524/4885ICMT 4670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.