Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29306640 | 0.82 | KMT2A (0.46) | KMT2AMEN1EGLN2ALDH1A1SMN1; SMN2 | |
| SCHEMBL19133478 | 0.82 | MEN1 (0.48) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7719747 | 0.81 | EPHX2 (0.52) | KMT2AMEN1MGLLALDH1A1CA12 | |
| SCHEMBL17623590 | 0.80 | KDM1A (0.49) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL25496774 | 0.80 | MEN1 (0.45) | IRAK4KMT2AMEN1EGLN2MGLL | |
| SCHEMBL23099474 | 0.79 | CDK2 (0.43) | EGLN2MGLL | |
| SCHEMBL17623699 | 0.79 | NAMPT (0.54) | KMT2AMEN1ALDH1A1SMN1; SMN2CA12 | |
| SCHEMBL6116171 | 0.77 | GPR119 (0.44) | KMT2AMEN1EGLN2ALDH1A1SMN1; SMN2 | |
| SCHEMBL24890614 | 0.77 | SMN1; SMN2 (0.58) | KMT2AMEN1EGLN2ALDH1A1SMN1; SMN2 | |
| SCHEMBL17623704 | 0.77 | TRPA1 (0.57) | KMT2AMEN1EGLN2ESRRGTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011571-B2 | Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound | SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2018-07-03 | — | — | US | disclosed |
| US-20170253566-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2017-09-07 | — | — | US | disclosed |
| WO-2016041472-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | 深圳微芯生物科技有限责任公司 | 2016-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10011571-B2 | Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound | JAK3, JAK1, JAK2 | IRAK4 22/4885KMT2A 999/4885MEN1 2717/4885 |
| US-20170253566-A1 | PREPARATION METHOD FOR AROMATIC HETEROCYCLIC COMPOUND USED AS SELECTIVE JAK3 AND/OR JAK1 KINASE INHIBITOR AND APPLICATION OF AROMATIC HETEROCYCLIC COMPOUND | JAK3, JAK1, JAK2 | IRAK4 22/4885KMT2A 999/4885MEN1 2717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.