Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.45 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 4/20 | 0.47 |
| ▸ | NPY4R | P50391 | 3/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17635841 | 0.91 | TGM2 (0.49) | TGM2MEN1USP2POLBPPARG | |
| Hydrochloric Acid SCHEMBL29539118 | 0.88 | USP2 (0.54) | TGM2MEN1USP2POLBPPARG | |
| SCHEMBL17409279 | 0.88 | TGM2 (0.53) | TGM2MEN1USP2POLBPPARG | |
| SCHEMBL22292200 | 0.87 | USP2 (0.55) | TGM2MEN1USP2POLBPPARG | |
| SCHEMBL17409206 | 0.87 | TGM2 (0.54) | TGM2MEN1USP2POLBPPARG | |
| SCHEMBL10123979 | 0.87 | USP2 (0.58) | TGM2MEN1USP2POLBPPARG | |
| Hydrochloric Acid SCHEMBL29557664 | 0.86 | USP2 (0.53) | TGM2MEN1USP2POLBPPARG | |
| SCHEMBL17635836 | 0.86 | TGM2 (0.53) | TGM2MEN1USP2POLBPPARG | |
| SCHEMBL18888026 | 0.85 | USP2 (0.53) | TGM2MEN1USP2POLBPPARG | |
| SCHEMBL18350813 | 0.85 | USP2 (0.53) | TGM2MEN1USP2POLBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016045782-A1 | FLUORESCENT PROTEIN STAINS | Universität Heidelberg (DE) | 2016-03-31 | — | — | WO | disclosed |
| EP-3001197-A1 | Fluorescent protein stains | Universität Heidelberg (DE) | 2016-03-30 | — | — | EP | disclosed |