Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1564195 | 0.85 | MAPT (0.47) | ACHEHPGDMEN1KMT2AMAPT | |
| SCHEMBL1415795 | 0.81 | ACHE (0.44) | ACHEHPGDCASP3AKR1C3AKR1C2 | |
| SCHEMBL3778231 | 0.79 | KMT2A (0.41) | HPGDCASP3MEN1KMT2AMAPT | |
| SCHEMBL17636740 | 0.77 | MAPT (0.48) | ACHEHPGDCASP3AKR1C3AKR1C2 | |
| SCHEMBL17040938 | 0.71 | MAPT (0.54) | ACHEHPGDMEN1KMT2ATDP1 | |
| SCHEMBL25839946 | 0.71 | NPSR1 (0.40) | ACHEHPGDKMT2AMAPTSLC6A3 | |
| SCHEMBL22983128 | 0.70 | MEN1 (0.43) | CASP3MEN1KMT2AMAPTLMNA | |
| SCHEMBL1415828 | 0.67 | TDP1 (0.48) | ACHEHPGDCASP3AKR1C3AKR1C2 | |
| SCHEMBL12986781 | 0.67 | CASP3 (0.54) | HPGDCASP3GAAALDH1A1KDM4E | |
| SCHEMBL1415410 | 0.66 | AKR1C3 (0.45) | AKR1C3AKR1C2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197452-B1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME (US) | 2020-02-26 | — | — | EP | disclosed |
| US-10208060-B2 | Inhibitors of HIF prolyl hydroxylase | MERCK SHARP & DOHME CORP. (US) | 2019-02-19 | — | — | US | disclosed |
| US-20170313718-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2017-11-02 | — | — | US | disclosed |
| EP-3197452-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049098-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313718-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | HIF1AN, EGLN2, EGLN3 | ACHE 4880/4885HPGD 91/4885CASP3 4460/4885 |
| US-10208060-B2 | Inhibitors of HIF prolyl hydroxylase | HIF1AN, EGLN2, EGLN3 | ACHE 4880/4885HPGD 91/4885CASP3 4460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.