Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 5/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17630030 | 0.81 | PLAU (0.43) | PLAURHEBKDM1AGRM5PTPN11 | |
| SCHEMBL17629890 | 0.78 | CYP11B2 (0.41) | CYP11B2NSD2 | |
| SCHEMBL17630009 | 0.78 | EGLN2 (0.40) | KDM1AGRM5CYP11B2NSD2 | |
| SCHEMBL17630044 | 0.77 | KDM1A (0.41) | KDM1APTPN11CYP11B2NSD2MAOB | |
| SCHEMBL17629945 | 0.75 | VCAM1 (0.47) | PLAUTDP1 | |
| SCHEMBL9140783 | 0.75 | RHEB (0.42) | PLAURHEBGSK3BCYP11B2NSD2 | |
| SCHEMBL17630012 | 0.74 | MMP3 (0.41) | PLAURHEBCCNB2CDK1CCNB1 | |
| SCHEMBL17630026 | 0.71 | KDM1A (0.41) | RHEBKDM1ACYP11B2NSD2MMP3 | |
| SCHEMBL10061101 | 0.71 | SLC22A12 (0.48) | RHEBCYP11B2 | |
| SCHEMBL17630049 | 0.71 | ADH5 (0.65) | CYP11B2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016046782-A1 | IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-03-31 | — | — | WO | disclosed |