SCHEMBL17629967

SCHEMBL17629967

Cc1nccn1CCCc1cc(C#N)ccc1I

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
MAPT P10636 1/20 0.45
CYP2C9 P11712 1/20 0.45
POLB P06746 1/20 0.44
KMT2A Q03164 1/20 0.44
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
TSHR P16473 1/20 0.36
KDM4E B2RXH2 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MEN1 O00255 1/20 0.35
P2RX7 Q99572 1/20 0.35
SETDB1 Q15047 1/20 0.35
ICMT O60725 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17672859 0.96 ALDH1A1 (0.45) ALDH1A1CYP1A2CYP3A4CYP2D6MAPT
SCHEMBL17630189 0.80 ALDH1A1 (0.41) ALDH1A1CYP1A2CYP3A4CYP2D6MAPT
SCHEMBL17679922 0.78 ALDH1A1 (0.40) ALDH1A1CYP1A2CYP3A4CYP2D6MAPT
SCHEMBL17672687 0.77 HTR1A (0.36) SETDB1HTR1A
SCHEMBL17672998 0.77 ALDH1A1 (0.39) ALDH1A1CYP1A2CYP3A4CYP2D6MAPT
SCHEMBL17630085 0.75 PDE3B (0.48) ALDH1A1CYP1A2CYP3A4CYP2D6MAPT
SCHEMBL17672585 0.75 USP14 (0.38) HTR1A
SCHEMBL17672572 0.75 TBXAS1 (0.50) ALDH1A1MAPTSMN1; SMN2
SCHEMBL17672843 0.75 CYP19A1 (0.48) HTR1A
SCHEMBL17672599 0.74 ALDH1A1 (0.38) ALDH1A1CYP1A2CYP3A4CYP2D6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016055947-A1 ALKYNE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2016-04-14 WO disclosed
WO-2016055947-A1 ALKYNE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2016-04-14 WO disclosed
WO-2016046782-A1 IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2016-03-31 WO disclosed
WO-2016046782-A1 IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2016-03-31 WO disclosed