Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.36 |
| ▸ | MTOR | P42345 | 5/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632087 | 0.91 | WNT1 (0.36) | WNT1GSK3BDYRK1AUSP30MTOR | |
| SCHEMBL17632053 | 0.89 | CHEK1 (0.40) | USP30CHEK1 | |
| SCHEMBL17631623 | 0.88 | CHEK1 (0.41) | WNT1GSK3BDYRK1AUSP30CHEK1 | |
| SCHEMBL17631988 | 0.86 | OTUD7B (0.42) | WNT1GSK3BDYRK1AUSP30PIK3CA | |
| SCHEMBL17632491 | 0.83 | CHEK1 (0.42) | WNT1GSK3BDYRK1AUSP30CHEK1 | |
| SCHEMBL17631806 | 0.82 | KDM1A (0.40) | WNT1GSK3BDYRK1AUSP30CHEK1 | |
| SCHEMBL17632487 | 0.81 | USP30 (0.41) | WNT1GSK3BDYRK1AUSP30CHEK1 | |
| SCHEMBL17632150 | 0.81 | USP30 (0.43) | USP30CHEK1RAB9AUCHL1SLC6A2 | |
| SCHEMBL17631680 | 0.81 | CHEK1 (0.40) | WNT1GSK3BDYRK1AUSP30CHEK1 | |
| SCHEMBL17632782 | 0.81 | CHEK1 (0.41) | USP30CHEK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |