Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | KIF20A | O95235 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1763184 | 1.00 | MAPT (0.53) | MAPTKIF20AALDH1A1KDM4EPOLB | |
| SCHEMBL13485336 | 0.85 | KIF20A (0.58) | MAPTKIF20AALDH1A1KDM4EPOLB | |
| SCHEMBL364137 | 0.83 | MAPT (0.58) | MAPTKIF20AALDH1A1KDM4EPOLB | |
| SCHEMBL364138 | 0.83 | MAPT (0.58) | MAPTKIF20AALDH1A1KDM4EPOLB | |
| SCHEMBL1762739 | 0.81 | MAPT (0.80) | MAPTKIF20AALDH1A1KDM4EPOLB | |
| SCHEMBL1762741 | 0.81 | MAPT (0.80) | MAPTKIF20AALDH1A1KDM4EPOLB | |
| SCHEMBL8519245 | 0.80 | ESR1 (0.63) | MAPTKIF20AALDH1A1KDM4EPOLB | |
| SCHEMBL6866609 | 0.79 | FBP1 (0.43) | MAPTALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL8401347 | 0.78 | KIF20A (0.51) | MAPTKIF20AALDH1A1KDM4EPOLB | |
| SCHEMBL8401348 | 0.78 | KIF20A (0.51) | MAPTKIF20AALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501691-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. Hoffmann-La Roche AG (CH) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061139-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-26 | — | — | WO | disclosed |
| US-20110118283-A1 | Substituted Pyrrolidine-2-Carboxamides | DING QINGJIE | 2011-05-19 | — | — | US | disclosed |
| US-20110118283-A1 | Substituted Pyrrolidine-2-Carboxamides | DING QINGJIE | 2011-05-19 | — | — | US | disclosed |
| US-20110118283-A1 | Substituted Pyrrolidine-2-Carboxamides | DING QINGJIE | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118283-A1 | Substituted Pyrrolidine-2-Carboxamides | ARG2, CPS1, PRMT3 | MAPT 4373/4885KIF20A 3146/4885ALDH1A1 863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.