Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16549367 | 1.00 | CYP2D6 (0.42) | CYP2D6HIF1AALDH1A1GMNNTP53 | |
| SCHEMBL16549365 | 0.81 | LMNA (0.46) | HSD17B10CYP2C19 | |
| SCHEMBL16549350 | 0.79 | KMT2A (0.33) | CYP2C9HSD17B10CYP2C19 | |
| SCHEMBL16549344 | 0.79 | PDF (0.38) | — | |
| SCHEMBL11437643 | 0.79 | CYP2D6 (0.50) | CYP2D6HIF1AGMNNTP53POLB | |
| SCHEMBL17347852 | 0.79 | CYP2D6 (0.50) | CYP2D6HIF1AGMNNTP53POLB | |
| SCHEMBL11437641 | 0.79 | CYP2D6 (0.50) | CYP2D6HIF1AGMNNTP53POLB | |
| SCHEMBL12387154 | 0.77 | CYP2D6 (0.48) | CYP2D6HIF1AALDH1A1GMNNTP53 | |
| SCHEMBL10081166 | 0.76 | CHRNB2 (0.33) | — | |
| SCHEMBL17811769 | 0.76 | CHRNB2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9720139-B2 | Polymerizable polysiloxanes with hydrophilic substituents | NOVARTIS AG (CH) | 2017-08-01 | — | — | US | disclosed |
| US-20170176643-A1 | POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS | ALCON INC. (CH) | 2017-06-22 | — | — | US | disclosed |
| US-9637582-B2 | Polymerizable polysiloxanes with hydrophilic substituents | NOVARTIS AG (CH) | 2017-05-02 | — | — | US | disclosed |
| US-20160090432-A1 | POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS | ALCON INC. (CH) | 2016-03-31 | — | — | US | disclosed |