Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | KHK | P50053 | 4/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589729 | 0.80 | ADRA2C (0.62) | CHKAADRB2NCF1PLD1KHK | |
| SCHEMBL7398706 | 0.79 | DRD2 (0.55) | CHKAADRB2NCF1PLD1KHK | |
| SCHEMBL18590696 | 0.78 | CHKA (0.67) | CHKAADRB2NCF1PLD1KHK | |
| SCHEMBL28112415 | 0.78 | CHKA (0.80) | CHKAADRB2NCF1PLD1MAPT | |
| SCHEMBL7398283 | 0.76 | MAPT (0.69) | KHKMAPTKDM4EGAADHFR | |
| SCHEMBL12525660 | 0.75 | AOC3 (0.57) | CHKAADRB2NCF1PLD1KHK | |
| SCHEMBL8634506 | 0.72 | CHKA (0.64) | CHKAADRB2NCF1PLD1MAPT | |
| SCHEMBL49273 | 0.69 | CHKA (1.00) | CHKAADRB2NCF1PLD1MAPT | |
| SCHEMBL19468905 | 0.69 | CHKA (0.90) | CHKAADRB2NCF1PLD1MAPT | |
| SCHEMBL23035473 | 0.69 | CHKA (0.64) | CHKAADRB2NCF1PLD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002278-A1 | GUANIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-06 | — | — | EP | disclosed |