Sugi Predict

Sugi Predict / Compounds / SCHEMBL1764938

SCHEMBL1764938

SCHEMBL1764938

CCOC(=O)c1cc(-c2cccc(C(F)(F)F)c2)n(-c2ccc(Cl)cc2)n1

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CHRNA7 P36544 2/20 0.61
▸ FAAH O00519 7/20 0.59
▸ MGLL Q99685 3/20 0.59
▸ CA9 Q16790 2/20 0.55
▸ RXRA P19793 1/20 0.48
▸ RXRB P28702 1/20 0.48
▸ RXRG P48443 1/20 0.48
▸ MALT1 Q9UDY8 1/20 0.48
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ PPP1CA P62136 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ TP53 P04637 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ GABRA2 P47869 1/20 0.47
▸ GABRB2 P47870 1/20 0.47
▸ RPA1 P27694 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2194152 0.92 FAAH (0.54) CHRNA7FAAHMGLLCA9SMN1; SMN2
SCHEMBL2193609 0.92 FAAH (0.60) CHRNA7FAAHMGLLCA9MEN1
SCHEMBL1764945 0.91 CHRNA7 (0.62) CHRNA7FAAHMGLLCA9MEN1
SCHEMBL1764943 0.91 FAAH (0.53) CHRNA7FAAHMGLLCA9MEN1
SCHEMBL1764964 0.89 FAAH (0.53) CHRNA7FAAHMGLLCA9SMN1; SMN2
SCHEMBL1764959 0.87 CHRNA7 (0.67) CHRNA7FAAHMGLLCA9MALT1
SCHEMBL1765415 0.87 CHRNA7 (0.64) CHRNA7FAAHMGLLCA9MALT1
SCHEMBL2192072 0.85 FAAH (0.57) CHRNA7FAAHMGLLCA9TP53
SCHEMBL1765057 0.85 LMNA (0.52) CHRNA7FAAHMGLLCA9RXRA
SCHEMBL3431433 0.84 RXRA (0.47) CHRNA7FAAHMGLLRXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
WO-2009115213-A1 (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES AICURIS GMBH & CO. KG (DE) 2009-09-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE TPMT, PAICS, THPO CHRNA7 3365/4885FAAH 4725/4885MGLL 4676/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.