Sugi Predict

Sugi Predict / Compounds / SCHEMBL1765057

SCHEMBL1765057

SCHEMBL1765057

CCOC(=O)c1cc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n(-c2cccc(Cl)c2)n1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.52
▸ TP53 P04637 1/20 0.52
▸ CHRNA7 P36544 3/20 0.52
▸ FAAH O00519 5/20 0.51
▸ ALDH1A1 P00352 1/20 0.49
▸ PPP1CA P62136 1/20 0.49
▸ CA9 Q16790 2/20 0.48
▸ GABRA2 P47869 1/20 0.48
▸ GABRB2 P47870 1/20 0.48
▸ NPY5R Q15761 1/20 0.48
▸ HTT P42858 1/20 0.47
▸ RXRA P19793 1/20 0.47
▸ RXRB P28702 1/20 0.47
▸ RXRG P48443 1/20 0.47
▸ MGLL Q99685 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1765268 0.94 LMNA (0.49) LMNATP53CHRNA7FAAHALDH1A1
SCHEMBL2194152 0.93 FAAH (0.54) LMNATP53CHRNA7FAAHALDH1A1
SCHEMBL1764964 0.90 FAAH (0.53) LMNATP53CHRNA7FAAHALDH1A1
SCHEMBL1764994 0.86 TP53 (0.55) LMNATP53CHRNA7FAAHALDH1A1
SCHEMBL1764934 0.86 LMNA (0.59) LMNATP53CHRNA7FAAHALDH1A1
SCHEMBL1764946 0.85 CHRNA7 (0.52) LMNATP53CHRNA7FAAHALDH1A1
SCHEMBL2193229 0.85 CA9 (0.65) LMNATP53CHRNA7FAAHALDH1A1
SCHEMBL1764938 0.85 CHRNA7 (0.61) LMNATP53CHRNA7FAAHPPP1CA
SCHEMBL1764878 0.84 TP53 (0.53) LMNATP53CHRNA7FAAHALDH1A1
SCHEMBL1765482 0.84 FAAH (0.56) LMNATP53CHRNA7FAAHALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
WO-2009115213-A1 (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES AICURIS GMBH & CO. KG (DE) 2009-09-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE TPMT, PAICS, THPO LMNA 1298/4885TP53 1099/4885CHRNA7 3365/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.