SCHEMBL17651778

SCHEMBL17651778

Oc1cccc(-c2c3nc(c(-c4cccc(O)c4)c4ccc([nH]4)c(-c4c(F)c(F)c(F)c(F)c4F)c4nc(c(-c5cccc(O)c5)c5ccc2[nH]5)C=C4)C=C3)c1

nearest known ligand 0.79

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ TOP1 P11387 1/20 0.43
▸ DHODH Q02127 1/20 0.42
▸ TERT O14746 3/20 0.42
▸ CYCS P99999 3/20 0.42
▸ ENPP2 Q13822 1/20 0.41
▸ STAT3 P40763 1/20 0.40
▸ STAT1 P42224 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17651811 1.00 TOP1 (0.43) TOP1DHODHTERTCYCSENPP2
SCHEMBL29556430 0.90 TOP1 (0.50) TOP1TERTCYCSENPP2STAT3
SCHEMBL31296593 0.90 TOP1 (0.50) TOP1TERTCYCSENPP2STAT3
SCHEMBL249199 0.90 TOP1 (0.50) TOP1TERTCYCSENPP2STAT3
SCHEMBL30297908 0.89 TERT (0.51) TOP1TERTCYCSENPP2STAT3
SCHEMBL8865323 0.89 TERT (0.51) TOP1TERTCYCSENPP2STAT3
SCHEMBL29648445 0.89 TERT (0.51) TOP1TERTCYCSENPP2STAT3
SCHEMBL17651785 0.86 TERT (0.40) TOP1DHODHTERTCYCSENPP2
SCHEMBL31679247 0.86 TERT (0.40) TOP1DHODHTERTCYCSENPP2
SCHEMBL1640992 0.86 TOP1 (0.54) TOP1TERTCYCSENPP2STAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3201201-B1 SPECIFICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2022-01-26 — — EP disclosed
EP-3201201-B1 SPECIFICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2022-01-26 — — EP disclosed
US-10738059-B2 Conjugates of porphyrinoid photosensitizers and glycerol-based polymers for photodynamic therapy BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2020-08-11 — — US disclosed
US-10456375-B2 Specifically meso-substituted porphyrins and chlorins for photodynamic therapy BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2019-10-29 — — US disclosed
US-10456375-B2 Specifically meso-substituted porphyrins and chlorins for photodynamic therapy BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2019-10-29 — — US disclosed
US-20180036284-A1 SPECIFICALLY meso-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2018-02-08 — — US disclosed
US-20180036284-A1 SPECIFICALLY meso-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2018-02-08 — — US disclosed
US-20180036284-A1 SPECIFICALLY meso-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2018-02-08 — — US disclosed
US-20170247384-A1 CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2017-08-31 — — US disclosed
EP-3210626-A1 CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY biolitec Unternehmensbeteiligungs II AG (AT) 2017-08-30 — — EP disclosed
EP-3201201-A1 SPECIFICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY biolitec unternehmensbeteiligungs II AG (AT) 2017-08-09 — — EP disclosed
WO-2016051361-A1 SPECIFICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2016-04-07 — — WO disclosed
WO-2016051361-A1 SPECIFICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG (AT) 2016-04-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180036284-A1 SPECIFICALLY meso-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY DHPS, DDT, PPOX TOP1 2038/4885DHODH 27/4885TERT 1760/4885
US-10456375-B2 Specifically meso-substituted porphyrins and chlorins for photodynamic therapy DHPS, DDT, PPOX TOP1 2038/4885DHODH 27/4885TERT 1760/4885
US-10738059-B2 Conjugates of porphyrinoid photosensitizers and glycerol-based polymers for photodynamic therapy FPGS, PPOX, UROD TOP1 661/4885DHODH 191/4885TERT 1979/4885
US-20170247384-A1 CONJUGATES OF PORPHYRINOID PHOTOSENSITIZERS AND GLYCEROL-BASED POLYMERS FOR PHOTODYNAMIC THERAPY FPGS, PPOX, UROD TOP1 661/4885DHODH 191/4885TERT 1979/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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