Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 16/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665681 | 0.90 | TDO2 (0.43) | TDO2IDO1 | |
| SCHEMBL17665353 | 0.85 | TDO2 (0.45) | TDO2IDO1 | |
| SCHEMBL17651997 | 0.80 | TDO2 (0.41) | TDO2IDO1 | |
| SCHEMBL17665680 | 0.80 | TDO2 (0.43) | TDO2IDO1 | |
| SCHEMBL17651963 | 0.80 | TDO2 (0.49) | TDO2IDO1 | |
| SCHEMBL17665333 | 0.79 | TDO2 (0.45) | TDO2IDO1PARP1OPRM1OPRD1 | |
| SCHEMBL17665352 | 0.77 | TDO2 (0.47) | TDO2IDO1 | |
| SCHEMBL17651977 | 0.76 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17665351 | 0.76 | TDO2 (0.48) | TDO2IDO1 | |
| SCHEMBL17651995 | 0.73 | TDO2 (0.46) | TDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |