Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | GLS | O94925 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268383 | 0.85 | GPR119 (0.47) | GPR119GLSEPHX2NAMPT | |
| SCHEMBL5272344 | 0.83 | GPR119 (0.43) | GPR119GLSEPHX2NAMPT | |
| SCHEMBL17654170 | 0.82 | GPR119 (0.65) | GPR119 | |
| SCHEMBL31508269 | 0.79 | BCAT2 (0.46) | GPR119GLSTRPC6BCAT2 | |
| SCHEMBL30986470 | 0.79 | HRH3 (0.42) | BCAT2 | |
| SCHEMBL16973181 | 0.79 | NAMPT (0.45) | GPR119EPHX2NAMPT | |
| SCHEMBL15972932 | 0.79 | GPR119 (0.38) | GPR119EPHX2SCD5NAMPT | |
| SCHEMBL14634473 | 0.79 | GPR119 (0.50) | GPR119GLSNAMPT | |
| SCHEMBL14634474 | 0.79 | GPR119 (0.50) | GPR119GLSNAMPT | |
| SCHEMBL18291613 | 0.77 | GPR119 (0.57) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11013724-B2 | Glutaminase inhibitors | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2021-05-25 | — | — | US | disclosed |
| US-20190167648-A1 | GLUTAMINASE INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-06-06 | — | — | US | disclosed |
| US-10245254-B2 | Glutaminase inhibitors | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2019-04-02 | — | — | US | disclosed |
| US-20170290815-A1 | GLUTAMINASE INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-10-12 | — | — | US | disclosed |
| WO-2016054388-A1 | GLUTAMINASE INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170290815-A1 | GLUTAMINASE INHIBITORS | GLUL, ASNS, GLS | GPR119 469/4885GLS 3/4885EPHX2 1810/4885 |
| US-10245254-B2 | Glutaminase inhibitors | GLUL, ASNS, GLS | GPR119 469/4885GLS 3/4885EPHX2 1810/4885 |
| US-20190167648-A1 | GLUTAMINASE INHIBITORS | GLUL, ASNS, GLS | GPR119 477/4885GLS 3/4885EPHX2 1848/4885 |
| US-11013724-B2 | Glutaminase inhibitors | GLUL, ASNS, GLS | GPR119 477/4885GLS 3/4885EPHX2 1848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.