Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17663880 | 0.82 | HSP90AB1 (0.40) | MEN1KMT2ALMNACYP2C9TSHR | |
| SCHEMBL17664085 | 0.82 | PARP1 (0.37) | PARP1LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL17664049 | 0.78 | PARP1 (0.35) | PARP1EGFR | |
| SCHEMBL17663941 | 0.76 | MEN1 (0.39) | PARP1MEN1KMT2ACYP17A1CYP11B1 | |
| SCHEMBL17664078 | 0.75 | MEN1 (0.39) | PARP1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL17664100 | 0.75 | FYN (0.41) | CYP17A1CYP11B1CYP11B2FYNMAPK14 | |
| SCHEMBL17664012 | 0.74 | SMN1; SMN2 (0.50) | MEN1KMT2ALMNACYP2C9TSHR | |
| SCHEMBL23716083 | 0.72 | TDP1 (0.35) | PARP1MEN1KMT2ACYP17A1CYP11B1 | |
| SCHEMBL23715848 | 0.72 | RAB9A (0.38) | MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3299911 | 0.71 | CYP17A1 (0.52) | CYP17A1CYP11B1CYP11B2MPOKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2016053855-A1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-07 | — | — | WO | disclosed |