Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.60 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.60 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736533 | 0.83 | IMPDH2 (0.64) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL3760031 | 0.80 | IMPDH2 (0.60) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL17506602 | 0.79 | IMPDH2 (0.69) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL14837630 | 0.78 | IMPDH2 (0.58) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL8161503 | 0.77 | IMPDH2 (0.56) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL6577130 | 0.77 | ALDH1A1 (0.53) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL17540776 | 0.76 | IMPDH2 (0.55) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL5797502 | 0.76 | IMPDH2 (0.55) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL7237886 | 0.75 | IMPDH2 (0.64) | IMPDH2IMPDH1GPR84ATMMEN1 | |
| SCHEMBL1752696 | 0.75 | IMPDH2 (0.64) | IMPDH2IMPDH1GPR84ATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294699-B1 | MODULATORS OF TNF- ALPHA SIGNALLING | GENZYME CORP (US) | 2016-04-13 | — | — | EP | claimed |