Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 5/20 | 0.48 |
| ▸ | KIT | P10721 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | BLK | P51451 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29375102 | 1.00 | KDR (0.69) | KDRPDGFRBRAB9AMAPTNPC1 | |
| SCHEMBL59552 | 0.88 | KDR (0.58) | KDRPDGFRBRAB9AMAPTNPC1 | |
| SCHEMBL19067997 | 0.88 | PDGFRB (0.55) | KDRPDGFRBRAB9AMAPTNPC1 | |
| SCHEMBL12491398 | 0.86 | PDGFRB (0.56) | KDRPDGFRBRAB9AMAPTNPC1 | |
| SCHEMBL31212719 | 0.85 | KDR (0.61) | KDRPDGFRBFLT3KITCA1 | |
| SCHEMBL57825 | 0.85 | KDR (0.61) | KDRPDGFRBFLT3KITCA1 | |
| SCHEMBL424260 | 0.84 | KDR (0.55) | KDRPDGFRBRAB9AMAPTNPC1 | |
| SCHEMBL59133 | 0.84 | KDR (0.51) | KDRPDGFRBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL422410 | 0.84 | NPC1 (0.59) | KDRPDGFRBRAB9AMAPTNPC1 | |
| SCHEMBL17200537 | 0.84 | PDGFRB (0.50) | KDRPDGFRBRAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145868-A1 | UREA INHIBITORS OF MICRO-RNA | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-05-11 | — | — | US | disclosed |
| US-20230145868-A1 | UREA INHIBITORS OF MICRO-RNA | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-05-11 | — | — | US | disclosed |
| US-20230145868-A1 | UREA INHIBITORS OF MICRO-RNA | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-05-11 | — | — | US | disclosed |
| US-11352343-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| WO-2022026380-A1 | UREA INHIBITORS OF MICRO-RNA | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-02-03 | — | — | WO | disclosed |
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2021-04-22 | — | — | US | disclosed |
| US-20200299272-A1 | Urea Derivatives and Uses Thereof | KALA BIO, Inc. | 2020-09-24 | — | — | US | disclosed |
| US-10723719-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20080076767-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBVIE INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080039491-A1 | SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2008-02-14 | — | — | US | disclosed |
| US-7297709-B2 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBOTT LABORATORIES (US) | 2007-11-20 | — | — | US | disclosed |
| EP-1845978-A1 | SUBSTITUTED PYRAZOLO-PYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | Aventis Pharma S.A. (FR) | 2007-10-24 | — | — | EP | disclosed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | disclosed |
| WO-2006077319-A1 | SUBSTITUTED PYRAZOLO-PYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2006-07-27 | — | — | WO | disclosed |
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050020603-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABBVIE INC. | 2005-01-27 | — | — | US | disclosed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | disclosed |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABBOTT LABORATORIES | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885RAB9A 3924/4885 |
| US-20080076767-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABL1, BLK, BTK | KDR 724/4885PDGFRB 549/4885RAB9A 3002/4885 |
| US-20050020603-A1 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors | ABL1, BLK, BTK | KDR 724/4885PDGFRB 549/4885RAB9A 3002/4885 |
| US-11352343-B2 | Urea derivatives and uses thereof | UACA, RB1, FLT1 | KDR 6/4885PDGFRB 1451/4885RAB9A 277/4885 |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABL1, MAP3K19, MAP3K1 | KDR 800/4885PDGFRB 631/4885RAB9A 2363/4885 |
| US-10723719-B2 | Urea derivatives and uses thereof | UACA, RB1, FLT1 | KDR 6/4885PDGFRB 1451/4885RAB9A 277/4885 |
| US-20200299272-A1 | Urea Derivatives and Uses Thereof | UACA, RB1, FLT1 | KDR 6/4885PDGFRB 1451/4885RAB9A 277/4885 |
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885RAB9A 3924/4885 |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885RAB9A 3924/4885 |
| US-20230145868-A1 | UREA INHIBITORS OF MICRO-RNA | HNRNPUL1, HNRNPUL2, EFTUD2 | KDR 4367/4885PDGFRB 4402/4885RAB9A 2973/4885 |
| US-20080039491-A1 | SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | DPYD, TYMP, PCK2 | KDR 2947/4885PDGFRB 1523/4885RAB9A 3211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.