Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22023647 | 0.82 | MAPT (0.43) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL24264489 | 0.79 | LMNA (0.49) | RAB9AALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL27588132 | 0.79 | MAPT (0.51) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL1346046 | 0.77 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL4779632 | 0.76 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL224315 | 0.74 | NPC1 (0.83) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL11365372 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL16324583 | 0.74 | HTT (0.67) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL224762 | 0.74 | NPC1 (0.88) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL29586231 | 0.73 | HSP90AA1 (0.64) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250002519-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2025-01-02 | — | — | US | disclosed |
| US-12071445-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2024-08-27 | — | — | US | disclosed |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-11603381-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2023-03-14 | — | — | US | disclosed |
| US-20210061834-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2021-03-04 | — | — | US | disclosed |
| US-20210061834-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2021-03-04 | — | — | US | disclosed |
| US-10894802-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2021-01-19 | — | — | US | disclosed |
| US-10894802-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2021-01-19 | — | — | US | disclosed |
| EP-3736279-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | Yale University (US) | 2020-11-11 | — | — | EP | disclosed |
| EP-3204395-B1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2020-05-27 | — | — | EP | disclosed |
| EP-3204395-B1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2020-05-27 | — | — | EP | disclosed |
| US-20170305948-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170305948-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170305948-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2017-10-26 | — | — | US | disclosed |
| EP-3204395-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | Yale University (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016057600-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | YALE UNIVERSITY (US) | 2016-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250002519-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | SMN1; SMN2 2929/4885NPC1 4247/4885RAB9A 2943/4885 |
| US-11603381-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | TIMCC, YAP1, TET2 | SMN1; SMN2 3274/4885NPC1 3836/4885RAB9A 3083/4885 |
| US-20210061834-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | SMN1; SMN2 2929/4885NPC1 4247/4885RAB9A 2943/4885 |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | SMN1; SMN2 2929/4885NPC1 4247/4885RAB9A 2943/4885 |
| US-20170305948-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | SMN1; SMN2 2929/4885NPC1 4247/4885RAB9A 2943/4885 |
| US-10894802-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | TIMCC, YAP1, TET2 | SMN1; SMN2 3274/4885NPC1 3836/4885RAB9A 3083/4885 |
| US-12071445-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | TIMCC, YAP1, TET2 | SMN1; SMN2 3274/4885NPC1 3836/4885RAB9A 3083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.