Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301715 | 0.80 | ACLY (0.50) | TLR7SLC40A1L3MBTL1TDP1KDM4E | |
| SCHEMBL8165111 | 0.80 | CA1 (0.51) | L3MBTL1MAPTKDM4EALDH1A1CYP3A4 | |
| SCHEMBL27804166 | 0.80 | COMT (0.44) | L3MBTL1MAPTKDM4EALDH1A1CYP3A4 | |
| SCHEMBL3914430 | 0.78 | MKNK1 (0.41) | SYKL3MBTL1MAPTKDM4EALDH1A1 | |
| SCHEMBL27726966 | 0.76 | CA2 (0.40) | SLC40A1GAATDP1ALDH1A1CA2 | |
| SCHEMBL18940878 | 0.75 | COMT (0.49) | L3MBTL1GAATDP1MAPTKDM4E | |
| SCHEMBL25296983 | 0.74 | MEN1 (0.48) | L3MBTL1MAPTKDM4EALDH1A1CYP3A4 | |
| SCHEMBL18960863 | 0.74 | MKNK1 (0.39) | SLC40A1L3MBTL1GAAMAPTKDM4E | |
| SCHEMBL29773169 | 0.74 | TLR7 (0.46) | TLR7 | |
| SCHEMBL28202739 | 0.74 | TLR7 (0.46) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3203840-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016057572-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | MILLER MARK THOMAS (US) | 2016-04-14 | — | — | WO | disclosed |