SCHEMBL17677012

SCHEMBL17677012

CC1(C)c2ccccc2-c2c1c1cc(-c3ccc(-n4c5ccccc5c5ccccc54)cc3)ccc1n2-c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ ATM Q13315 1/20 0.43
▸ HDAC4 P56524 1/20 0.37
▸ IL1R1 P14778 1/20 0.35
▸ KMT2A Q03164 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ PGR P06401 3/20 0.34
▸ PTGER4 P35408 1/20 0.34
▸ TSPO P30536 1/20 0.33
▸ AKR1C4 P17516 1/20 0.31
▸ AKR1C3 P42330 1/20 0.31
▸ AKR1C2 P52895 1/20 0.31
▸ AKR1C1 Q04828 1/20 0.31
▸ MAPK8 P45983 1/20 0.30
▸ RORC P51449 1/20 0.30
▸ EDNRA P25101 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17677032 0.93 L3MBTL1 (0.40) L3MBTL1KDM4EATMHDAC4IL1R1
SCHEMBL17677095 0.93 PGR (0.38) L3MBTL1KDM4EATMIL1R1KMT2A
SCHEMBL17677089 0.92 L3MBTL1 (0.44) L3MBTL1KDM4EATMHDAC4IL1R1
SCHEMBL15759540 0.90 KDM4E (0.35) L3MBTL1KDM4EATMHDAC4PTGER4
SCHEMBL15759578 0.90 KDM4E (0.35) L3MBTL1KDM4EATMHDAC4PTGER4
SCHEMBL15860855 0.89 L3MBTL1 (0.42) L3MBTL1KDM4EATMHDAC4IL1R1
SCHEMBL17689930 0.89 L3MBTL1 (0.44) L3MBTL1KDM4EATMHDAC4IL1R1
SCHEMBL17667135 0.89 L3MBTL1 (0.46) L3MBTL1KDM4EATMHDAC4IL1R1
SCHEMBL15860849 0.88 L3MBTL1 (0.41) L3MBTL1KDM4EATMHDAC4IL1R1
SCHEMBL15860806 0.88 PTGER4 (0.35) L3MBTL1KDM4EATMHDAC4IL1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006426-B1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO LTD (JP) 2019-01-09 — — EP disclosed
US-9985216-B2 Indenoindole derivative and organic electroluminescent element HODOGAYA CHEMICAL CO., LTD. (JP) 2018-05-29 — — US disclosed
US-9985216-B2 Indenoindole derivative and organic electroluminescent element HODOGAYA CHEMICAL CO., LTD. (JP) 2018-05-29 — — US disclosed
US-20160126468-A1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO., LTD. (JP) 2016-05-05 — — US disclosed
US-20160126468-A1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO., LTD. (JP) 2016-05-05 — — US disclosed
EP-3006426-A1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT Hodogaya Chemical Co., Ltd. (JP) 2016-04-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160126468-A1 INDENOINDOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT IDO2, SLCO2B1, IDO1 L3MBTL1 2737/4885KDM4E 922/4885ATM 3172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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