Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP2 | P42575 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683574 | 0.82 | LMNA (0.39) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL22056582 | 0.79 | FAAH (0.41) | FAAHKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL649228 | 0.79 | POLB (0.39) | KMT2ASMN1; SMN2ALDH1A1MEN1TSHR | |
| SCHEMBL17669630 | 0.78 | ECE1 (0.42) | KMT2AL3MBTL1TSHRLMNA | |
| SCHEMBL2149503 | 0.74 | TSHR (0.46) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL22351756 | 0.74 | EPHX1 (0.52) | SMN1; SMN2ALDH1A1TSHREPHX1 | |
| SCHEMBL4496590 | 0.73 | CNR1 (0.42) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL12424179 | 0.73 | FAAH (0.50) | FAAHKMT2AALDH1A1MEN1MCL1 | |
| SCHEMBL12673154 | 0.73 | KMT2A (0.58) | FAAHKMT2AALDH1A1MEN1MCL1 | |
| SCHEMBL19027370 | 0.72 | POLB (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9539338-B2 | Polymer-based protein engineering methods to rationally tune enzyme activity, pH-dependence and stability | CARNEGIE MELLON UNIVERSITY (US) | 2017-01-10 | — | — | US | disclosed |
| US-20160101190-A1 | POLYMER-BASED PROTEIN ENGINEERING METHODS TO RATIONALLY TUNE ENZYME ACTIVITY, pH-DEPENDENCE AND STABILITY | CARNEGIE MELLON UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160101190-A1 | POLYMER-BASED PROTEIN ENGINEERING METHODS TO RATIONALLY TUNE ENZYME ACTIVITY, pH-DEPENDENCE AND STABILITY | DNPEP, PEPD, ANPEP | FAAH 350/4885KMT2A 1447/4885SMN1; SMN2 3174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.