Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | CPS1 | P31327 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13398 | 0.86 | CPS1 (0.46) | HTR1FALDH1A1KMT2AMEN1MGLL | |
| SCHEMBL1173693 | 0.79 | DGAT1 (0.44) | HTR1FALDH1A1KMT2AMEN1MGLL | |
| SCHEMBL6896656 | 0.76 | MEN1 (0.51) | HTR1FALDH1A1KMT2AMEN1MGLL | |
| SCHEMBL28026652 | 0.76 | CES2 (0.52) | HTR1FALDH1A1KMT2AMEN1CES2 | |
| SCHEMBL28026650 | 0.76 | CES2 (0.52) | HTR1FALDH1A1KMT2AMEN1CES2 | |
| SCHEMBL16006491 | 0.75 | CES2 (0.43) | ALDH1A1KMT2AMEN1CES2CES1 | |
| SCHEMBL14553949 | 0.75 | CES2 (0.43) | ALDH1A1CES2CES1TSHRLMNA | |
| SCHEMBL17682929 | 0.75 | CPS1 (0.59) | ALDH1A1KMT2AMEN1MGLLCPS1 | |
| SCHEMBL23612343 | 0.73 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1MGLLMAPT | |
| SCHEMBL29591363 | 0.73 | CES2 (0.56) | ALDH1A1KMT2AMEN1MGLLCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |