Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349013 | 0.82 | TSHR (0.45) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL8859640 | 0.82 | ALDH1A1 (0.45) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL2961735 | 0.82 | TSHR (0.45) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL6421785 | 0.80 | ALDH1A1 (0.48) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL6421789 | 0.80 | ALDH1A1 (0.48) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL13816225 | 0.80 | TSHR (0.43) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL26539118 | 0.80 | ALDH1A1 (0.43) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL7069601 | 0.80 | ALDH1A1 (0.48) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL20373431 | 0.78 | TSHR (0.42) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A | |
| SCHEMBL18964893 | 0.78 | ALDH1A1 (0.38) | TSHRALDH1A1RAB9AKDM4EAPOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160102075-A1 | UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102075-A1 | UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | PDE10A, PDE2A, PDE3A | TSHR 2124/4885ALDH1A1 526/4885RAB9A 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.