Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 4/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383093 | 0.82 | GRM5 (0.51) | SMARCA2SMARCA4GRM5SORT1CSF1R | |
| SCHEMBL2826318 | 0.82 | GRM5 (0.54) | SMARCA2SMARCA4GRM5SORT1PORCN | |
| Hydrochloric Acid SCHEMBL17685482 | 0.80 | KMT2A (0.45) | KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL2826560 | 0.75 | GRM5 (0.46) | SMARCA2SMARCA4GRM5PIK3CANPC1 | |
| SCHEMBL15663675 | 0.73 | GRM5 (0.52) | SMARCA2SMARCA4GRM5SORT1PORCN | |
| SCHEMBL17685495 | 0.72 | PORCN (0.49) | SMARCA2SMARCA4GRM5SORT1PORCN | |
| SCHEMBL2833088 | 0.72 | GRM5 (0.56) | SMARCA2SMARCA4GRM5SORT1PORCN | |
| SCHEMBL15663974 | 0.71 | GRM5 (0.53) | SMARCA2SMARCA4GRM5PORCNHDAC3 | |
| SCHEMBL4141530 | 0.71 | HCAR2 (0.40) | GRM5GRM4PIK3CA | |
| SCHEMBL2831334 | 0.71 | GRM5 (0.54) | SMARCA2SMARCA4GRM5SORT1PORCN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858862-B1 | PYRAZINE -2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | claimed |