Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 2/20 | 0.49 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685484 | 0.82 | MAPT (0.51) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL15890225 | 0.79 | PORCN (0.68) | PORCNSMARCA2SMARCA4MAPTMAPK1 | |
| SCHEMBL1383789 | 0.79 | GRM5 (0.51) | SMARCA2SMARCA4MAPTMAPK1SORT1 | |
| SCHEMBL25821628 | 0.79 | PORCN (0.55) | PORCNSMARCA2SMARCA4MAPTMAPK1 | |
| SCHEMBL24010293 | 0.75 | ALDH1A1 (0.52) | PORCNSMARCA2SMARCA4MAPTMAPK1 | |
| SCHEMBL9828922 | 0.73 | SMARCA2 (0.69) | SMARCA2SMARCA4MAPTMAPK1LMNA | |
| SCHEMBL25820900 | 0.73 | SMARCA2 (0.61) | SMARCA2SMARCA4MAPTMAPK1LMNA | |
| SCHEMBL31129258 | 0.73 | SMARCA2 (0.64) | PORCNSMARCA2SMARCA4MAPK1SORT1 | |
| SCHEMBL2826714 | 0.72 | GRM5 (0.70) | PORCNSMARCA2SMARCA4MAPTGRM5 | |
| SCHEMBL17685478 | 0.72 | SMARCA2 (0.47) | PORCNSMARCA2SMARCA4SORT1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858862-B1 | PYRAZINE -2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | claimed |