Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790225 | 0.86 | PARP1 (0.47) | PARP1ROCK2BRD4LMNAROCK1 | |
| SCHEMBL23095470 | 0.85 | GAA (0.53) | PARP1LMNATP53MAPTMETAP2 | |
| SCHEMBL13753059 | 0.83 | CES2 (0.55) | PARP1BRD4LMNAMAPTL3MBTL1 | |
| SCHEMBL19954264 | 0.82 | PARP1 (0.45) | PARP1ROCK2BRD4LMNAROCK1 | |
| SCHEMBL12900909 | 0.81 | LMNA (0.49) | BRD4LMNAMAPTL3MBTL1GAA | |
| SCHEMBL5906696 | 0.80 | LMNA (0.44) | PARP1ROCK2BRD4LMNATP53 | |
| SCHEMBL13382055 | 0.80 | LMNA (0.44) | PARP1BRD4LMNATP53L3MBTL1 | |
| SCHEMBL10202756 | 0.79 | ALDH1A1 (0.51) | PARP1ROCK2ROCK1MAPTMETAP2 | |
| SCHEMBL11888130 | 0.79 | METAP2 (0.51) | PARP1LMNAMETAP2RAB9A | |
| SCHEMBL11918972 | 0.78 | TP53 (0.54) | LMNATP53MAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9315542-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2016-04-19 | — | — | US | disclosed |