Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | FABP3 | P05413 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10107719 | 0.85 | ALDH2 (0.68) | RAB9ANPC1POLBCHRM4MAPT | |
| SCHEMBL3620383 | 0.82 | RAB9A (0.70) | RAB9ANPC1POLBCHRM4MAPT | |
| SCHEMBL13149469 | 0.81 | RAB9A (0.78) | RAB9ANPC1POLBCHRM4MAPT | |
| SCHEMBL10107753 | 0.81 | ALDH2 (0.73) | RAB9ANPC1POLBALDH2MEN1 | |
| SCHEMBL20051405 | 0.79 | RAB9A (0.66) | RAB9ANPC1POLBCHRM4MAPT | |
| SCHEMBL8360215 | 0.78 | MMP13 (0.69) | RAB9ANPC1POLBCHRM4MAPT | |
| SCHEMBL8358827 | 0.77 | RAB9A (0.61) | RAB9ANPC1POLBCHRM4MAPT | |
| SCHEMBL8357425 | 0.75 | MMP13 (0.72) | RAB9ANPC1POLBCHRM4MAPT | |
| SCHEMBL10107738 | 0.74 | TP53 (0.68) | NPC1POLBALDH2MEN1LMNA | |
| SCHEMBL17241709 | 0.74 | RAB9A (0.57) | RAB9ANPC1POLBCHRM4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160107996-A1 | Mitochondrial Aldehyde Dehyrogenase-2 Modulators and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2016-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160107996-A1 | Mitochondrial Aldehyde Dehyrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, SHMT2 | RAB9A 4172/4885NPC1 2651/4885POLB 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.