Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768825 | 0.85 | MEN1 (0.54) | NPC1RAB9ASMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL28472074 | 0.84 | NAAA (0.59) | NPC1RAB9ASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL27993602 | 0.82 | NAAA (0.61) | NPC1RAB9ASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL28181763 | 0.81 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL10872706 | 0.78 | RAB9A (0.56) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL28212893 | 0.77 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL20392869 | 0.75 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL2033165 | 0.75 | MAPK1 (0.73) | NPC1RAB9AMAPK1HDAC3HDAC4 | |
| SCHEMBL215253 | 0.74 | HDAC1 (0.51) | NPC1RAB9AHDAC3HDAC4HDAC1 | |
| SCHEMBL18435782 | 0.74 | HDAC1 (0.51) | NPC1RAB9AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011095218-A1 | TEMPLATE-FIXED PEP TIDOMIME TICS WITH CXCR7 MODULATING ACTIVITY | POLYPHOR AG (CH) | 2011-08-11 | — | — | WO | disclosed |
| WO-2011060832-A1 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY | POLYPHOR AG (CH) | 2011-05-26 | — | — | WO | disclosed |