Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | HTR3A | P46098 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.46 |
| ▸ | HTR3B | O95264 | 2/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19878791 | 0.88 | HTR2C (0.52) | DRD2HTR3AHTR1AHTR3EHTR3B | |
| SCHEMBL19878869 | 0.88 | HTR2C (0.52) | DRD2HTR3AHTR1AHTR3EHTR3B | |
| SCHEMBL1769816 | 0.81 | DRD2 (0.47) | DRD2SIGMAR1CYP2D6ADORA2AGRIN1 | |
| SCHEMBL1352305 | 0.80 | DRD2 (0.44) | DRD2HTR3AHTR1AHTR3EHTR3B | |
| SCHEMBL11594479 | 0.80 | DRD2 (0.66) | DRD2HTR1AHTR2CSIGMAR1CYP2D6 | |
| SCHEMBL22432745 | 0.78 | HTR3A (0.65) | DRD2HTR3AHTR1AHTR3EHTR3B | |
| SCHEMBL1350975 | 0.78 | HTR3E (0.46) | DRD2HTR3AHTR1AHTR3EHTR3B | |
| SCHEMBL6110571 | 0.78 | DRD2 (0.45) | DRD2SIGMAR1CYP2D6GRIN1GRIN2B | |
| SCHEMBL1351568 | 0.77 | HTR3E (0.47) | DRD2HTR3AHTR1AHTR3EHTR3B | |
| SCHEMBL24639876 | 0.75 | HTR2A (0.58) | DRD2HTR3AHTR1AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112104-A1 | TRICYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | LES LABORATOIRES SERVIER (FR) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112104-A1 | TRICYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | BAX, CASP3, BCL2 | DRD2 2186/4885HTR3A 707/4885HTR1A 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.