Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 14/20 | 0.82 |
| ▸ | ACVR1 | Q04771 | 14/20 | 0.82 |
| ▸ | BMPR1A | P36894 | 13/20 | 0.82 |
| ▸ | BMPR1B | O00238 | 12/20 | 0.82 |
| ▸ | ACVR1B | P36896 | 11/20 | 0.82 |
| ▸ | KDR | P35968 | 5/20 | 0.82 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.82 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.82 |
| ▸ | BMPR2 | Q13873 | 4/20 | 0.82 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.82 |
| ▸ | BMP4 | P12644 | 6/20 | 0.71 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.71 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.71 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29389388 | 0.93 | ACVR1B (0.83) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL17817805 | 0.93 | ACVR1B (0.83) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL16025991 | 0.90 | ACVR1 (1.00) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL29391702 | 0.90 | ACVR1 (1.00) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| Hydrochloric Acid SCHEMBL30388107 | 0.89 | ACVR1 (0.98) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL17531631 | 0.85 | ACVRL1 (0.83) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL17531641 | 0.85 | ACVRL1 (0.84) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL17531635 | 0.84 | ACVRL1 (0.84) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL31060242 | 0.84 | ACVR1B (1.00) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B | |
| SCHEMBL19660993 | 0.83 | ACVR1B (1.00) | ACVRL1ACVR1BMPR1ABMPR1BACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160115167-A1 | BMP INHIBITORS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160115167-A1 | BMP INHIBITORS AND METHODS OF USE THEREOF | BMP1, BMPR2, BMP2 | ACVRL1 14/4885ACVR1 13/4885BMPR1A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.