Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | PTAFR | P25105 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15103054 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1ALOX15SIGMAR1PTAFR | |
| SCHEMBL9744374 | 0.84 | ALDH1A1 (0.57) | KDM4EALDH1A1ALOX15SIGMAR1PTAFR | |
| SCHEMBL5714375 | 0.76 | KDM4E (0.46) | KDM4EALDH1A1ALOX15SIGMAR1PTAFR | |
| SCHEMBL6103199 | 0.74 | TRPV1 (0.48) | KDM4EALDH1A1ALOX15SIGMAR1HTR2A | |
| SCHEMBL5714468 | 0.74 | KDM4E (0.49) | KDM4EALDH1A1ALOX15SIGMAR1PTAFR | |
| SCHEMBL6103020 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1ALOX15SIGMAR1PTAFR | |
| SCHEMBL5714874 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1ALOX15SIGMAR1PTAFR | |
| SCHEMBL5714238 | 0.74 | SIGMAR1 (0.53) | KDM4EALDH1A1ALOX15SIGMAR1EPHX2 | |
| SCHEMBL6101747 | 0.74 | SIGMAR1 (0.47) | KDM4EALDH1A1ALOX15SIGMAR1PTAFR | |
| SCHEMBL5715177 | 0.74 | SIGMAR1 (0.44) | KDM4EALDH1A1ALOX15SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615089-B1 | Pyrazoloquinoline compounds | ASTELLAS PHARMA INC (JP) | 2016-04-27 | — | — | EP | disclosed |