Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PRKDC | P78527 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27936855 | 0.80 | LRRK2 (0.59) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL11981573 | 0.79 | TP53 (0.49) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL21807926 | 0.79 | LMNA (0.46) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL30321663 | 0.79 | LGMN (0.53) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL31051506 | 0.79 | LMNA (0.46) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL114416 | 0.79 | LGMN (0.53) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL3304237 | 0.79 | LMNA (0.46) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL3724026 | 0.79 | LMNA (0.46) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL30900618 | 0.79 | LMNA (0.46) | LGMNLMNACDK1CDK2PIK3CA | |
| SCHEMBL25718631 | 0.79 | LMNA (0.46) | LGMNLMNACDK1CDK2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768834-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-27 | — | — | EP | disclosed |