Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 3/20 | 0.46 |
| ▸ | XDH | P47989 | 3/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17708383 | 0.92 | ALDH1A1 (0.49) | ALDH1A1HPGDARXDHS1PR1 | |
| SCHEMBL12180531 | 0.85 | ALDH1A1 (0.51) | ALDH1A1HPGDARXDHS1PR1 | |
| SCHEMBL15337643 | 0.83 | AR (0.47) | ALDH1A1HPGDAR | |
| SCHEMBL14228267 | 0.83 | ALDH1A1 (0.57) | ALDH1A1HPGDARXDH | |
| SCHEMBL4694901 | 0.81 | AR (0.57) | ALDH1A1HPGDARXDH | |
| SCHEMBL12433115 | 0.81 | ALDH1A1 (0.66) | ALDH1A1HPGDAR | |
| SCHEMBL17708071 | 0.80 | XDH (0.47) | ALDH1A1HPGDARXDHS1PR1 | |
| SCHEMBL15337378 | 0.80 | AR (0.50) | ALDH1A1HPGDAR | |
| SCHEMBL12180520 | 0.78 | AR (0.49) | ALDH1A1HPGDARXDH | |
| SCHEMBL20195705 | 0.78 | XDH (0.47) | ALDH1A1HPGDARXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160257681-A1 | Protein Kinase C Inhibitors and Uses Thereof | MIDCAP FINANCIAL TRUST | 2016-09-08 | — | — | US | disclosed |
| US-9321763-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2016-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160257681-A1 | Protein Kinase C Inhibitors and Uses Thereof | PRKCH, PRKCA, PRKCB | ALDH1A1 4361/4885HPGD 1581/4885AR 4567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.