SCHEMBL177086

SCHEMBL177086

Oc1ccc2cn[nH]c2c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 8/20 0.72
FGFR2 P21802 3/20 0.72
FGFR3 P22607 1/20 0.72
NOS1 P29475 3/20 0.59
MAPT P10636 3/20 0.59
DYRK1A Q13627 2/20 0.59
METAP2 P50579 2/20 0.59
KDM4E B2RXH2 2/20 0.59
MEN1 O00255 1/20 0.59
PKM P14618 1/20 0.59
HTT P42858 1/20 0.59
KMT2A Q03164 1/20 0.59
CYP3A4 P08684 2/20 0.53
ALDH1A1 P00352 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
HIF1A Q16665 1/20 0.53
PHLPP2 Q6ZVD8 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29741144 1.00 FGFR1 (0.72) FGFR1FGFR2FGFR3NOS1MAPT
Fumaric Acid SCHEMBL6361834 0.86 FGFR1 (0.57) FGFR1FGFR2FGFR3NOS1MAPT
Fumaric Acid SCHEMBL6361838 0.86 FGFR1 (0.57) FGFR1FGFR2FGFR3NOS1MAPT
SCHEMBL14663812 0.84 FGFR1 (1.00) FGFR1FGFR2FGFR3NOS1MAPT
SCHEMBL29520931 0.83 ROCK2 (0.59) FGFR1FGFR2FGFR3NOS1MAPT
SCHEMBL277777 0.83 ROCK2 (0.59) FGFR1FGFR2FGFR3NOS1MAPT
Hydrochloric Acid SCHEMBL27782875 0.81 ROCK2 (0.57) FGFR1FGFR2FGFR3NOS1MAPT
SCHEMBL29741168 0.79 FGFR1 (0.49) FGFR1FGFR2FGFR3NOS1MAPT
SCHEMBL24046742 0.74 NOS1 (0.59) FGFR1FGFR2FGFR3NOS1MAPT
SCHEMBL9529035 0.74 NOS1 (0.59) FGFR1FGFR2FGFR3NOS1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 532 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3386511-B2 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2024-03-20 EP claimed
CN-116102566-A Preparation method and application of indazole-modified rhodamine mercury ion probe 上海前瞻创新研究院有限公司 2023-05-12 CN claimed
EP-3814357-A1 HETEROCYCLIC AND HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC Therapeutics, Inc. (US) 2021-05-05 EP claimed
CN-107987057-A The preparation method of Axitinib and its intermediate 王兆举 2018-05-04 CN claimed
CN-105734586-B A kind of organic-silicon-modified corrosion inhibitor and preparation method thereof 中国石油化工股份有限公司 2018-04-10 CN claimed
US-9486892-B2 Polishing composition FUJIMI INCORPORATED (JP) 2016-11-08 US claimed
CN-105734586-A Organosilicon-modified corrosion inhibitor and preparation method thereof 中国石油化工股份有限公司 2016-07-06 CN claimed
CN-104523682-A Application of 6-hydroxy-1-hydro-indazole in preparation of medicine for preventing and treating neurodegenerative disease WANG WENYA 2015-04-22 CN claimed
US-20090039811-A1 Inhibitors of HSP90 CHENE PATRICK 2009-02-12 US claimed
CN-101027053-A Hsp90 inhibitor NOVARTIS AG (CH) 2007-08-29 CN claimed
WO-2007071686-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, AN OXIDATION BASE AND A PARTICULAR COUPLER L'ORÉAL (FR) 2007-06-28 WO claimed
EP-1773327-A1 INHIBITORS OF HSP90 Novartis AG (CH) 2007-04-18 EP claimed
WO-2006010595-A1 INHIBITORS OF HSP90 NOVARTIS AG (CH) 2006-02-02 WO claimed
US-20040231067-A1 Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses L'OREAL (FR) 2004-11-25 US claimed
EP-1428510-A1 Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, and a heterocyclic coupler or a hydroxybenzamide ; method and use L'OREAL (FR) 2004-06-16 EP claimed
US-4168953-A Oxidation hair dyes based upon tetraaminopyrimidine developers and monohydroxyindazole couplers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1979-09-25 US claimed
EP-4743079-A2 APOL1 INHIBITORS AND METHODS OF USE THEREOF Maze Therapeutics, Inc. (US) 2026-05-20 EP disclosed
EP-4720038-A1 (HETERO)ARYL-CARBONYL-HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PMS2 FOR CANCER AND DEGENERATIVE ILLNESSES Neophore Limited (GB) 2026-04-08 EP disclosed
US-3939142-A Phenylazophenyl dyestuff HOECHST AKTIENGESELLSCHAFT (DT) 1976-02-17 US disclosed
US-3939084-A Functional fluid compositions containing substituted pyrimidines MONSANTO COMPANY (US) 1976-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040231067-A1 Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses KRT18, CDC73, PYCR1 FGFR1 1023/4885FGFR2 861/4885FGFR3 397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.