Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PPM1B | O75688 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17710221 | 1.00 | PARP1 (0.43) | PARP1ALDH1A1HPGDPPM1BLOXL2 | |
| SCHEMBL17710246 | 0.86 | PARP1 (0.45) | PARP1ALDH1A1HPGDPPM1BLOXL2 | |
| SCHEMBL17710216 | 0.86 | PARP1 (0.45) | PARP1ALDH1A1HPGDPPM1BLOXL2 | |
| SCHEMBL17710223 | 0.81 | TSHR (0.46) | PARP1ALDH1A1HPGDPPM1BLOXL2 | |
| SCHEMBL17710174 | 0.80 | PARP1 (0.37) | PARP1ALDH1A1HPGDPPM1BLOXL2 | |
| SCHEMBL17710190 | 0.77 | PARP1 (0.43) | PARP1ALDH1A1PPM1BLOXL2KDM4E | |
| SCHEMBL24586212 | 0.76 | LOXL2 (0.46) | ALDH1A1HPGDLOXL2KDM4EKMT2A | |
| SCHEMBL9156970 | 0.76 | HTR2C (0.41) | — | |
| SCHEMBL1417028 | 0.76 | RAB9A (0.49) | PARP1ALDH1A1PPM1BLOXL2KDM4E | |
| SCHEMBL3933287 | 0.74 | KMO (0.54) | ALDH1A1HPGDPPM1BLOXL2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212184-B1 | SUBSTITUTED BENZOTETRAHYDROPYRANS AND THEIR USE | ABBVIE OVERSEAS SARL (LU) | 2020-04-01 | — | — | EP | disclosed |
| EP-3212184-A1 | SUBSTITUTED TETRAHYDROPYRANS AND METHOD OF USE | Abbvie S.a.r.l. (LU) | 2017-09-06 | — | — | EP | disclosed |
| US-9567322-B2 | Substituted tetrahydropyrans and method of use | ABBVIE S.Á.R.L. (LU) | 2017-02-14 | — | — | US | disclosed |
| WO-2016069891-A1 | SUBSTITUTED TETRAHYDROPYRANS AND METHOD OF USE | ABBVIE INC. (US) | 2016-05-06 | — | — | WO | disclosed |
| US-20160122331-A1 | SUBSTITUTED TETRAHYDROPYRANS AND METHOD OF USE | ABBVIE OVERSEAS S.Á.R.L. (LU) | 2016-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122331-A1 | SUBSTITUTED TETRAHYDROPYRANS AND METHOD OF USE | CFTR, MRPL21, TACR1 | PARP1 3964/4885ALDH1A1 1377/4885HPGD 703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.