Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 9/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819074 | 0.83 | KDM1A (0.34) | KDM1AKCNH2KDM1B | |
| SCHEMBL17711502 | 0.82 | AR (0.41) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL17711243 | 0.82 | AR (0.41) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL17711413 | 0.80 | KDM4E (0.33) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL24901421 | 0.78 | MEN1 (0.39) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL1568066 | 0.78 | PDE2A (0.38) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL30730980 | 0.78 | PDE2A (0.38) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL17355421 | 0.78 | KDM1A (0.36) | KDM1AKCNH2KDM1B | |
| SCHEMBL29509660 | 0.73 | AR (0.44) | MEN1KMT2AKDM4EMAPTHSD17B10 | |
| SCHEMBL17709992 | 0.73 | AR (0.44) | MEN1KMT2AKDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112979630-A | Trifluoromethanols as Ror gamma t modulators | 詹森药业有限公司 | 2021-06-18 | — | — | CN | disclosed |
| EP-3354651-B1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2021-01-06 | — | — | EP | disclosed |
| EP-3212643-B1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-03-20 | — | — | EP | disclosed |
| US-10150762-B2 | Trifluoromethyl alcohols as modulators of RORγt | JANSSEN PHARMACEUTICA, NV (BE) | 2018-12-11 | — | — | US | disclosed |
| EP-3354651-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica N.V. (BE) | 2018-08-01 | — | — | EP | disclosed |
| US-9850236-B2 | Trifluoromethyl alcohols as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2017-12-26 | — | — | US | disclosed |
| US-9850236-B2 | Trifluoromethyl alcohols as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2017-12-26 | — | — | US | disclosed |
| US-9850236-B2 | Trifluoromethyl alcohols as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2017-12-26 | — | — | US | disclosed |
| US-20170327492-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-16 | — | — | US | disclosed |
| US-20170327492-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-16 | — | — | US | disclosed |
| US-20170327492-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-16 | — | — | US | disclosed |
| US-20160122336-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160122336-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160122336-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122336-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | RORC, RORA, RORB | MEN1 4211/4885KMT2A 1096/4885KDM4E 1927/4885 |
| US-20170327492-A1 | TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt | RORA, RORC, RORB | MEN1 4262/4885KMT2A 707/4885KDM4E 1048/4885 |
| US-10150762-B2 | Trifluoromethyl alcohols as modulators of RORγt | RORC, RORA, RORB | MEN1 4423/4885KMT2A 323/4885KDM4E 843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.