Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16485445 | 0.82 | KDM4E (0.58) | SYKSMN1; SMN2AURKBINCENPKDM4E | |
| SCHEMBL1073540 | 0.80 | SYK (0.68) | SYKSMN1; SMN2AURKBINCENPKDM4E | |
| SCHEMBL791890 | 0.79 | FFAR1 (0.61) | SYKAURKBINCENPABCB1HTR1A | |
| SCHEMBL4856658 | 0.78 | SYK (0.53) | SYKSMN1; SMN2AURKBINCENPKDM4E | |
| SCHEMBL28025324 | 0.78 | SYK (0.59) | SYKSMN1; SMN2AURKBINCENPKDM4E | |
| SCHEMBL28153213 | 0.78 | KDM4E (0.53) | SYKSMN1; SMN2AURKBINCENPKDM4E | |
| SCHEMBL15271054 | 0.77 | SMN1; SMN2 (0.57) | SYKSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL15475165 | 0.77 | ALDH1A1 (0.59) | SYKSMN1; SMN2AURKBINCENPKDM4E | |
| SCHEMBL26580976 | 0.77 | KDM4E (0.51) | SYKSMN1; SMN2AURKBINCENPKDM4E | |
| SCHEMBL15474712 | 0.76 | SYK (0.53) | SYKSMN1; SMN2AURKBINCENPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212647-A2 | NOVEL PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATING THE CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS) | Dong-A ST Co., Ltd. (KR) | 2017-09-06 | — | — | EP | claimed |
| WO-2016068580-A2 | NOVEL PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATING THE CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS) | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2016-05-06 | — | — | WO | claimed |