Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274826 | 0.76 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL30099834 | 0.75 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL8194 | 0.75 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL9980433 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL19445102 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL130023 | 0.74 | CYP1A2 (0.55) | ALDH1A1KDM4EMAPTCYP1A2ATAD2 | |
| SCHEMBL12066725 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL2009983 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL4141544 | 0.74 | BCHE (0.44) | ALDH1A1KDM4EMAPTNPC1POLB | |
| SCHEMBL335171 | 0.74 | HTT (0.53) | ALDH1A1KDM4EMAPTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213112-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2022-07-07 | — | — | US | claimed |
| US-20190337957-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2019-11-07 | — | — | US | claimed |
| EP-3542801-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAP-RELATED DISEASES | Boehringer Ingelheim International GmbH (DE) | 2019-09-25 | — | — | EP | claimed |
| EP-2119717-B1 | 8-[3-amino-piperidin-1-yl]-xanthins, their production and utilisation as DPP IV inhibitors | BOEHRINGER INGELHEIM INT (DE) | 2018-01-17 | — | — | EP | claimed |
| US-20160136180-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2016-05-19 | — | — | US | claimed |
| US-8697868-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-04-15 | — | — | US | claimed |
| CN-1980930-B | 8- [ 3-amino-piperidin-1-yl ] -xanthines, their preparation and their use in the form of DPP-IV inhibitors | BOEHRINGER INGELHEIM INT | 2012-11-21 | — | — | CN | claimed |
| CN-102199151-A | 8-[3-amino-piperidin-1-yl]-xanthine, the production thereof and the use | BOEHRINGER INGELHEIM INT | 2011-09-28 | — | — | CN | claimed |
| US-20110112069-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-12 | — | — | US | claimed |
| CN-102015651-A | Compounds and compositions as TLR activity modulators | IRM LLC | 2011-04-13 | — | — | CN | claimed |
| EP-2190434-A2 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | Boehringer Ingelheim International GmbH (DE) | 2010-06-02 | — | — | EP | claimed |
| US-20090137801-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-28 | — | — | US | claimed |
| EP-1758905-B1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINE, THE PRODUCTION THEREOF AND THE USE IN THE FORM OF A DDP-IV INHIBITOR | BOEHRINGER INGELHEIM INT (DE) | 2009-04-29 | — | — | EP | claimed |
| WO-2009024542-A2 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-26 | — | — | WO | claimed |
| CN-1980930-A | 8- [ 3-amino-piperidin-1-yl ] -xanthines, their preparation and their use in the form of DPP-IV inhibitors | BOEHRINGER INGELHEIM INT (DE) | 2007-06-13 | — | — | CN | claimed |
| US-20050234108-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-20 | — | — | US | claimed |
| US-20220213112-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2022-07-07 | — | — | US | disclosed |
| US-11220510-B2 | Pyrrole tricyclic compounds as A2A / A2B inhibitors | INCYTE CORPORATION (US) | 2022-01-11 | — | — | US | disclosed |
| US-20050234235-A1 | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-20 | — | — | US | disclosed |
| CN-1469878-A | Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | — | 2004-01-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234235-A1 | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions | DPP4, DPP3, DPP8 | ALDH1A1 1010/4885KDM4E 455/4885MAPT 399/4885 |
| US-20190337957-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | ADORA2A, ADORA2B, ADORA1 | ALDH1A1 1049/4885KDM4E 4183/4885MAPT 2815/4885 |
| US-20090137801-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | DPP8, DPP4, DPP7 | ALDH1A1 276/4885KDM4E 1036/4885MAPT 295/4885 |
| US-20220213112-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | ADORA2A, ADORA2B, ADORA1 | ALDH1A1 1049/4885KDM4E 4183/4885MAPT 2815/4885 |
| US-11220510-B2 | Pyrrole tricyclic compounds as A2A / A2B inhibitors | ADORA2A, ADORA2B, ADORA1 | ALDH1A1 1049/4885KDM4E 4183/4885MAPT 2815/4885 |
| US-20050234108-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions | DPP8, DPP4, DPP7 | ALDH1A1 287/4885KDM4E 1140/4885MAPT 330/4885 |
| US-20160136180-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | PNP, ENTPD5, NUDT14 | ALDH1A1 3607/4885KDM4E 3292/4885MAPT 4548/4885 |
| US-20110112069-A1 | PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAB-RELATED DISEASES | PNP, PURB, NUDT14 | ALDH1A1 3774/4885KDM4E 2873/4885MAPT 4630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.