Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17725671 | 0.93 | ALDH1A1 (0.64) | ALDH1A1TP53L3MBTL1KMT2AMEN1 | |
| SCHEMBL17725705 | 0.90 | ALDH1A1 (0.60) | ALDH1A1TP53L3MBTL1KMT2AMEN1 | |
| SCHEMBL17725703 | 0.90 | ALDH1A1 (0.58) | ALDH1A1TP53L3MBTL1KMT2AMEN1 | |
| SCHEMBL17725695 | 0.89 | ALDH1A1 (0.57) | ALDH1A1TP53L3MBTL1KMT2AMEN1 | |
| SCHEMBL19566999 | 0.89 | ALDH1A1 (0.65) | ALDH1A1TP53KMT2AMEN1HSD17B10 | |
| SCHEMBL19549075 | 0.87 | ALDH1A1 (0.66) | ALDH1A1TP53KMT2AMEN1HSD17B10 | |
| SCHEMBL19549088 | 0.85 | KMT2A (0.66) | ALDH1A1TP53KMT2AMEN1HSD17B10 | |
| SCHEMBL17725590 | 0.84 | ALDH1A1 (0.64) | ALDH1A1TP53L3MBTL1KMT2ALMNA | |
| SCHEMBL17725778 | 0.84 | LMNA (0.73) | ALDH1A1TP53L3MBTL1KMT2AHSD17B10 | |
| SCHEMBL19567003 | 0.84 | LMNA (0.67) | ALDH1A1TP53L3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212644-B1 | DERIVATIVES OF 2-(1,2,4-TRIAZOL-3-YLSULFANYL)-N-1,3,4-THIADIAZOL-2-YL ACETAMIDE WHICH ARE USEFUL FOR THE TREATMENT OF DIABETES | APOGLYX AB (SE) | 2021-05-05 | — | — | EP | disclosed |
| US-10011597-B2 | Derivatives of 2-(1,2,4-triazol-3-ylsulfanyl)-N-1,3,4-thiadiazol-2-yl acetamide which are useful for the treatment of inter alia diabetes | APOGLYX AB (SE) | 2018-07-03 | — | — | US | disclosed |
| US-10011597-B2 | Derivatives of 2-(1,2,4-triazol-3-ylsulfanyl)-N-1,3,4-thiadiazol-2-yl acetamide which are useful for the treatment of inter alia diabetes | APOGLYX AB (SE) | 2018-07-03 | — | — | US | disclosed |
| US-20170320869-A1 | DERIVATIVES OF 2-(1,2,4-TRIAZOL-3-YLSULFANYL)-N-1,3,4-THIADIAZOL-2-YL ACETAMIDE WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA DIABETES | APOGLYX AB (SE) | 2017-11-09 | — | — | US | disclosed |
| US-20170320869-A1 | DERIVATIVES OF 2-(1,2,4-TRIAZOL-3-YLSULFANYL)-N-1,3,4-THIADIAZOL-2-YL ACETAMIDE WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA DIABETES | APOGLYX AB (SE) | 2017-11-09 | — | — | US | disclosed |
| WO-2016066696-A1 | DERIVATIVES OF 2-(1,2,4-TRIAZOL-3-YLSULFANYL)-N-1,3,4-THIADIAZOL-2-YL ACETAMIDE WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA DIABETES | APOGLYX AB (SE) | 2016-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320869-A1 | DERIVATIVES OF 2-(1,2,4-TRIAZOL-3-YLSULFANYL)-N-1,3,4-THIADIAZOL-2-YL ACETAMIDE WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA DIABETES | AQP1, AQP3, AQP4 | ALDH1A1 1327/4885TP53 3220/4885L3MBTL1 4344/4885 |
| US-10011597-B2 | Derivatives of 2-(1,2,4-triazol-3-ylsulfanyl)-N-1,3,4-thiadiazol-2-yl acetamide which are useful for the treatment of inter alia diabetes | AQP1, AQP3, AQP4 | ALDH1A1 1327/4885TP53 3220/4885L3MBTL1 4344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.